Effects of in Vitro Glycation on Fe3+ Binding and Fe3+ Isoforms of Transferrin
نویسندگان
چکیده
منابع مشابه
Effects of in vitro glycation on Fe3+ binding and Fe3+ isoforms of transferrin.
BACKGROUND In diabetes, protein function is altered by glycation, but the impact on the Fe3+ binding and antioxidant functions of transferrin (Tf) is largely unknown. The aim of the present study was to investigate the effects of glycation on the distribution of Fe3+ on the two Fe3+ -binding sites of Tf. METHODS In vitro glycation of Tf was accomplished by preincubation with glucose for 14 da...
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A new type of apo-Tf functionalized nanochannel is developed to achieve the specific and selective binding and unbinding of Fe(3+) in a multiple and reversible manner via a protein-conformation-gating mechanism. This ion-responsive biomimetic nanochannel provides a simple, robust, and promising model for studying other biological processes.
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2004
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2004.033811